DYING CHANCE –
Aug. 25, 2026 – If you are carrying naloxone for a family member, friend, client, student or someone in your community, seeing two different strengths can raise a reasonable question: If one nasal spray contains 4 mg of naloxone and another contains 8 mg, is the higher dose better?
The answer is not as simple as “more is better.”
A real-world study published by the Centers for Disease Control and Prevention compared 4 mg and 8 mg intranasal naloxone used by New York State Police during suspected opioid overdoses. Researchers found no statistically significant difference in survival or in the average number of naloxone doses administered. They did, however, find that opioid-withdrawal signs and symptoms were reported more often among people who received the 8 mg product. Read the CDC’s 4 mg vs. 8 mg naloxone study.
